PHARMACOVIGILANCE SIGNALS OF THE OPIOID EPIDEMIC OVER 10 YEARS: DATA MINING METHODS IN THE ANALYSIS OF PHARMACOVIGILANCE DATASETS COLLECTING ADVERSE DRUG REACTIONS (ADRS) REPORTED TO EUDRAVIGILANCE (EV) AND THE FDA ADVERSE EVENT REPORTING SYSTEM (FAERS)

In the past twenty years, the consumption of opioid medications has reached significant proportions, leading to a rise in drug misuse and abuse and increased opioid dependence and related fatalities.Thus, the purpose of this study was to determine whether there are pharmacovigilance signals of abuse, misuse, and dependence and their nature for the

9G Solar energy is a green and sustainable clean energy source.Its rational use can alleviate the energy crisis and environmental pollution.Directly converting solar energy into heat energy is the most efficient method among all solar conversion strategies.Recently, various environmental and energy applications based on nanostructured photothermal

AmpC beta-lactamases cause resistance to third-generation cephalosporins, including beta-lactamase inhibitors.In Escherichia coli from the German food production chain, the majority of AmpC beta-lactamase activity can be attributed to plasmid-mediated CMY-2 or overproduction of chromosomal AmpC beta-lactamase, but occasionally other enzymes like DH

Abstract Background Aedes aegypti and Ae.albopictus are important human arbovirus vectors that can spread arboviral diseases such as yellow fever, dengue, chikungunya and Zika.These two mosquito species coexist on Hainan Island and the Leizhou Peninsula in China.Over the past 40 years, the distribution of Ae.albopictus in these areas has gradually

The Golgi cells are the main inhibitory interneurons of the cerebellar granular layer.Although recent works have highlighted the complexity of FOOT their dendritic organization and synaptic inputs, the mechanisms through which these neurons integrate complex input patterns remained unknown.Here we have used 8 detailed morphological reconstructions